Chemical Exposures: Low Levels and High Stakes, 2nd edition 1998
by Nicholas Ashford and Claudia Miller
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Latest Publications
Perales RB, Palmer RF, Rincon R, Viramontes JN, Walker T, Jaén CR, Miller CS. (2022) Does improving indoor air quality lessen symptoms associated with chemical intolerance? Primary Health Care Research & Development 23(e3): 1–12.
This study describes the results of our Environmental House Calls demonstrating improved symptoms among those with chemical intolerance who improved the indoor air quality as a result of our recommendations.
Palmer RF, Walker T, Perales RB, Rincon R, Jaén CR, Miller CS. Disease comorbidities associated with chemical intolerance.
intolerance. Environ Dis 2021;6:134-41.
This paper reveals a list of chronic diseases reported by those with and without chemical intolerance. Those with chemical intolerance experience more chronic illnesses compared to those without chemical intolerance
Palmer RF, Jae´n CR, Perales RB, Rincon R, Forster JN, Miller CS (2020) Three questions for identifying chemically intolerant individuals in clinical and epidemiological populations: The Brief Environmental Exposure and Sensitivity Inventory (BREESI). PLoS ONE 15(9): e0238296.
Our first demonstration that a brief 3-item survey is an excellent screener for chemical intolerance. Used in our clinical study of 200 individuals, the BREESI correctly classified those with chemical intolerance when validated with our 50-item survey (QEESI). This is an excellent tool for screening chemical intolerance in a busy health care clinic.
Palmer, R.F.; Walker, T.; Kattari, D.; Rincon, R.; Perales, R.B.; Jaén, C.R.; Grimes, C.; Sundblad, D.R.; Miller, C.S. Validation of a Brief Screening Instrument for Chemical Intolerance in a Large U.S. National Sample. Int. J. Environ. Res. Public Health 2021, 18, 8714.
Our second demonstration that a brief 3-item survey is an excellent screener for chemical intolerance. This was tested in a US population sample of over 10,000 participants. Again, the BREESI correctly classified chemical intolerance 90% of the time. This is an excellent tool for screening chemical intolerance in epidemiological or other survey research.
Miller, C.S., Palmer, R.F., Dempsey, T.T. Ashford, N. Mast cell activation may explain many cases of chemical intolerance. Environ Sci Eur 33, 129 (2021).
This paper provides for the first time a plausible biological mechanism for chemical intolerance. Overactive mast cells may be responsible for the various symptoms experienced by those with CI. Some dietary and medical interventions are discussed.
Masri, S., Miller, C.S., Palmer, R.F. et al. Toxicant-induced loss of tolerance for chemicals, foods, and drugs: assessing patterns of exposure behind a global phenomenon. Environ Sci Eur 33, 65 (2021).
This study is a review of the chemical intolerance phenomena in terms of the exposures that can initiate the disease.
Publications
Chemical Intolerance in Primary Care Settings: Prevalence, Comorbidity and Outcomes
Katerndahl, DA, Miller CS. Ann Fam Med. 2012; 10(4):357 – 65.
The Compelling Anomaly of Chemical Intolerance
Miller CS. Ann NY Acad Sci. 2001; 933:1-23
Miller CS. Toxicol Ind Health. 1999; 15 (3-4): 284-94.
Toxicant-Induced Loss of Tolerance–an Emerging Theory of Disease?
Miller CS. Environ Health Perspect. 1997;105 Suppl 2:445-53.
Empirical Approaches for the Investigation of Toxicant-Induced Loss of Tolerance.
Miller CS, Ashford NA, Doty R, Lamielle M, Otto D, Rahill A, Wallace L. Envrion Health Perspect. 1997; 105 Suppl 2:515-19.
Chemical Sensitivity: Symptom, Syndrome or Mechanism for Disease?
Miller CS. Toxicology. 1996; 111:69-86.
Other Publications on Chemical Intolerance
Heilbrun LP, Palmer RF, Jaen CR, Svoboda MD, Perkins J, Miller CS. Maternal Chemical and Drug Intolerances: Potential Risk Factors for Autism and Attention Deficit Hyperactivity Disorder (ADHD). J Am Board Fam Med. 2015;28(4):461-70.
Toxicant-Induced Loss of Tolerance. Addiction.
Miller CS. Toxicant-induced loss of tolerance. Addiction. 2001;96(1):115-37.
Self-reported Sensitivity to Chemical Exposures in Five Clinical Populations and Healthy Controls
Nawab SS, Miller CS, Dale JK, Greenberg BD, Friedman TC, Straus SE, Chrousos GP, Rosenthal NE. Psychiatry Res. 2000; 95(1):67-74.
Exacerbation of Chemical Sensitivity: a Case Study
Miller CS, Gammage RB, Jankovic JT. Exacerbation of chemical sensitivity: a case study. Toxicol Ind Health. 1999;15(3-4):398-402.
Miller CS, Prihoda TJ. A controlled comparison of symptoms and chemical intolerances reported by Gulf War veterans, implant recipients and persons with multiple chemical sensitivity. Toxicol Ind Health. 1999;15(3-4):386-97.
Miller CS, Prihoda. Toxicol Ind Health. 1999;15 (3-4): 370-85.