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Marilyn Hoffman Chemical Intolerance Program

Chemical intolerance is characterized by multisystem symptoms triggered by low levels of exposure to chemicals, foods/food additives, and drugs/medications. Prevalence estimates are estimated to be 20% of the population. Toxicant‐Induced Loss of Tolerance (TILT) is the mechanistic process that initiates CI. Learn more on this website.


Our overarching goal is to develop informed lay and health professionals who recognize and address the environmental and medical challenges associated with TILT.


Through our research, we identify environmental triggers, best practices for prevention and intervention, and potential biological markers for chemical intolerance and its mechanism Toxicant Induced Loss of Tolerance (TILT).


Our outreach efforts focus on those afflicted with chemical intolerance, the general public and specific groups that would benefit from understanding Chemical Intolerance and TILT; such as architects, contractors, beauticians and first responders.

1 in 5

have Chemical Intolerance


of our time is spent indoors where the air often is more polluted than the air outside

I had severe muscle pain, night sweats, skin rashes, severe exhaustion. A real brain fog – that was probably the worst symptom for me.

Jane Little, BBC Reporter