Our team at the Toxicant-Induced Loss of Tolerance (TILT) Program at UT Health San Antonio wanted to share this important external study:
“Cognitive Benefits of Reducing Indoor Particulate Matter Exposure During Sleep: New Evidence from a Randomized, Double-blind Crossover Trial,” published in the journal Environmental Science & Technology.
The study, led by researchers at Peking University in Beijing, explores the cognitive effects of indoor particulate matter (PM) pollution exposure during sleep and the potential cognitive benefits of reducing such exposure.
Sleep is critical for cognitive health and occupies about one-third of human life.
This randomized, double-blind crossover intervention trial was conducted among 80 college students with real and sham PM filtration in their dormitories. Real-time indoor PM levels and nocturnal sleep parameters were monitored, followed by quantification of serum neurotransmitter metabolites and cognitive assessments in the mornings. We found that PM exposure during sleep, particularly PM1 and PM2.5, affected immediate and delayed memory, executive function, and global cognition. Reducing PM exposure during sleep resulted in improvements in multiple cognitive domains, with a 0.21 (95% CI: 0.05, 0.36) increase in global cognitive z-score, in which increased sleep oxygen saturation (SpO2) and alterations in dopamine metabolism and histidine metabolism played important roles. Notably, even when indoor PM2.5 levels were below the WHO air quality guidelines, further reducing PM exposure could still improve sleep SpO2 and neurotransmitter metabolism. This study provides a promising strategy to mitigate indoor PM-induced cognitive impairment.
This issue is important for people who suffer from chemical intolerance (CI), said Dr. Claudia Miller, allergist/immunologist, professor emeritus, and leader of the Hoffman TILT Program at UT Health San Antonio.
How can you find out if you have chemical intolerance?
Answer these three questions from the TILT Program on Chemical Intolerance:
- Do you feel sick when you are exposed to tobacco smoke, certain fragrances, nail polish/remover, engine exhaust, gasoline, air fresheners, pesticides, paint/thinner, fresh tar/asphalt, cleaning supplies, new carpet or furnishings? By sick, we mean: headache, difficulty thinking, difficulty breathing, weakness, dizziness, upset stomach, etc.
- Are you unable to tolerate or do you have adverse or allergic reactions to any drugs or medications (such as antibiotics, anesthetics, pain relievers, X-ray contrast dye, vaccines or birth control pills), or to an implant, prosthesis, contraceptive chemical or device, or other medical/surgical/dental material or procedure?
- Are you unable to tolerate or do you have adverse reactions to any foods such as dairy products, wheat, corn, eggs, caffeine, alcoholic beverages, or food additives (e.g., MSG, food dye)?
If you answer YES to any question, take the Quick Environmental Exposure and Sensitivity Inventory (QEESI) and share the results with your doctor!